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At the same time, transformation stories online often underplay the less glamorous realities: Muscle loss alongside fat loss Nutritional compromise from severely reduced intake Hair loss, fatigue, nausea, and GI adverse effects Weight regain after discontinuation Psychological pressure surrounding body image Unsupervised or socially influenced use Perhaps the most important point: these medications were never meant to replace lifestyle modification

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In other words, metformin isn't just a glucose-lowering drugit's a top-down rewiring agent for gut nutrient sensing and hormone modulation, which likely underlies the benefits observed across so many organ systems