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Several plausible explanations include: insufficient autophagy suppression in patient tumors by HCQ, the dual role of autophagy inhibition in suppressing tumor metabolism and proliferation while potentially promoting metastasis, and the current lack of suitable pharmacodynamic biomarkers (66, 106, 107)

Post-marketing surveillance studies gather real-world data on the drugs performance, identifying any long-term effects that may not have been apparent during clinical trials
Understanding the causes of constipation can help you manage symptoms: 1

N Engl J Med 2015;373:2247-2257