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Despite a substantial body of evidence implicating abnormalities in intracellular Ca 2+ dynamics in the pathophysiology of bipolar disorder, the specific Ca 2+ -signalling defects in the brain that underpin the characteristic manic and depressive behaviours remains unclear

Intriguingly, it appears that taste does not only contribute to obesity, but is also affected by obesity as accumulating evidence suggests that the primary taste tissue, the tongue, is an obesity target organ [8,9]

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