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However, available extension studies suggest that the benefits of dual agonism are maintained over time, with some patients experiencing continued improvement beyond the initial treatment period
[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Seino Y, Terauchi Y, Osonoi T, Yabe D, Abe N, Nishida T, et al
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A study in The Journal of Clinical Investigation demonstrated that glucagon infusion increases energy expenditure by 100 to 200 calories per day (4), and retatrutide replicates this effect through sustained receptor activation
