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Additionally, it has been recommended to shorten follow-up periods for patients using a GLP-1 agonist for more frequent screenings (6 to 12 weeks), especially if DR is present or the patient reports vision loss since their last visit

Pregnant or Breastfeeding Women: The safety of semaglutide during pregnancy and lactation is not well studied

Gallstone pancreatitis should not be considered a contraindication to GLP-1/GIP therapy after cholecystectomy, though a history of recent pancreatitis should give one pause in prescribing a GLP-1/GIP agonist

These issues are typically linked to indirect effects such as gastrointestinal symptoms, altered eating patterns, or nocturnal hypoglycaemia rather than a direct pharmacological action