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Weight loss appears to play a meaningful role, since adipose tissue is a known driver of pro-inflammatory cytokines
TRIUMPH-1 enrolled approximately 2,300 patients and is expected to complete around mid-year

Both semaglutide fatigue and tirzepatide tiredness are well-documented, and crossing multiple time zones makes both significantly worse

Several international anesthesia societies have issued updated guidance to mitigate these risks, yet available evidence remains limited and sometimes inconsistent
