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The World Health Organization now describes obesity as a chronic, relapsing disease and recommends GLP-1 therapies as part of long-term obesity treatment, alongside diet, physical activity and support from health professionals

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Regarding dual GLP-1/GIP receptor agonists, DA-JC1 has been observed to have a neuroprotective effect in an MPTP mouse model [58,59,60], as well as in a cell culture experiment, in SH-SY5Y cells with ROT-induced mitochondrial stress [35], which was also superior to older GLP-1 analogs [61]