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Description
Lower cravings They act on the brains appetite centres, reducing the urge to snack or overeat
Furthermore, while both GIP and GLP-1 exert protective effects on the vasculature under normal glucose levels, only GLP-1 enhances endothelial function in states of hyperglycemia
Clinical trial outcomes (15% weight loss for Wegovy, 20% for Zepbound) are from studies of FDA-approved products under controlled conditions - they don't predict compounded product results or any individual's outcome
Even though this phenomenon has not been fully understood in the context of the possible exacerbation of pro-depressive changes by GLP-1RA administration, it certainly requires careful investigation before the potential introduction of these compounds to the clinic for the treatment of mood disorders in the future