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Airway protection is important in immediate management, and antihistamines, corticosteroids, or sympathomimetics such as epinephrine can be administered if severe

Possible side effects include: Side effects are often more noticeable when starting semaglutide or increasing the dose

In individuals with overweight or obesity, treatment with semaglutide was associated with significant reductions in bodyweight, with a mean placebo-subtracted weight loss of 12.4% relative to placebo after 68 weeks reported in the STEP 1 trial

Combination with SGLT2 inhibitors to augment the benefits of this drug class in HFrEF with, for example, the weight-lowering effects of GLP-1 RA could offer a clinically valuable and feasible option addressing the spectrum of abnormalities associated with this HF phenotype