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Cost Impact and Equity of Access The high cost of GLP-1RAs presents a significant barrier to widespread access, especially in LMICs

According to the latest Global Diabetes Map (10th edition) released by the International Diabetes Federation (IDF) in December 2021, the number of people aged 20 to 79 with diabetes worldwide was estimated at 537 million in 2021, with the number expected to grow to 700 million by 2045

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Consistent with these effects, GLP-1 RAs have been associated with substantial weight loss in clinical trials, leading to FDA approval of two of these agents liraglutide and semaglutide for chronic weight management in adults with obesity or with overweight and at least one weight-related comorbidity