semaglutide cause joint pain for Weight Loss and Ozempic and GLP-1 Drugs: Risk

This narrative review synthesizes data from randomized controlled trials (RCTs) and real-world evidence (RWE) on Wegovy (semaglutide 2.4 mg, a recombinant DNA-derived GLP-1RA) in obesity with CVD, with a focus on SELECT, mediation analyses suggesting weight-independent CV effects, and outcomes in obesity-related HFpEF

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Patients were stratified according to exposure (n=106,454) or non-exposure (n=317,698) to once-weekly semaglutide, and incidence rates and hazard ratios (HR) of NAION were estimated in a multivariable Cox proportional hazard regression model