glp 1 analogue Multifaceted Roles of GLP-1 and Its Analogs: A Review on Molecular Mechanisms with a Cardiotherapeutic Perspective Unlock the Potential of GLP-1

doi: 10.2337/db17-0480 23 KoffertJHonkaHTeuhoJKauhanenSHurmeSParkkolaRet al

Indications: FDA approved: Type II diabetes - monotherapy or combination therapy Can be combined as adjunct therapy with other hypoglycemics including metformin, thiazolidinediones, or insulin regimens (Dungan & DeSantis 2015) Because it does not work when your blood sugar is low, it is unlikely to produce dangerous levels of hypoglycemia has been observed in clinical trials (in contrast to GLP-1 incretin mimetics, such as exenatide, which produce moderate weight loss)

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Multi-omics analyses revealed that liraglutide increased the abundance of Lactobacillus delbrueckii , which in turn restored the levels of the endocannabinoid 2-arachidonoylglycerol (2-AG)