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In the Saxenda clinical trials, participants were asked to follow a reduced-calorie diet and exercise at least 150 minutes each week, in addition to using the medication

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Significant weight loss was achieved 12 months after the initiation of pharmacotherapy and the weight loss was higher in the semaglutide group than in the liraglutide group [47]

[11] Drug interactions listed on the package insert include delayed or reduced concentrations of lovastatin, paracetamol (acetaminophen), and digoxin, although this has not been proven to alter the effectiveness of these other medications
