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Buprenorphine, also an opioid, also has a significant long-term side effect profile, including over 60% of patients reporting sleep disturbances that may interfere with treatment

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For GLP-1, the review confirmed insulinotropic effects on -cells during hyperglycaemia, glucagonostatic effects on -cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity

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