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Description
When looking at the entire group, the weight change after 14 weeks was minimal in the placebo group (+0.5%), but the TE groups showed weight reductions of -0.5%, -0.9%, -1.32%, and -2.32% for different doses of TE

5 Clinical evidence shows that GLP-1RAs may provide similar glycemic control to insulin with lower risk of hypoglycemia

A mediation analysis of the SUSTAIN 15 trials showed minor contribution of nausea/vomiting to the greater weight reduction during the therapy with once-weekly semaglutide versus its comparators

And the 86-degree threshold is a hard ceiling, not a recommendation
