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Clinical considerations: Formulation matters
Male ob/ob mice were subcutaneously injected with liraglutide daily for 4 weeks, fatty acid synthase (FASN) was down-regulated through the MAPK/ERK and PKA signaling pathways (11)

it represents a breakthrough in metabolic medicine

French physiologist Jean La Barre first used the term incretine in 1932 to describe a substance which lowered glucose levels by augmenting insulin release and actions.4 5 We now know that GLP-1 and glucose-dependent insulinotropic peptide (GIP) are the two main incretin hormones
