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GLP-1R polymorphism (rs1042044) and expression are associated with the risk of papillary thyroid cancer among the Egyptian population

Many patients and providers view semaglutide as a chronic management tool similar to how blood pressure medications maintain cardiovascular health long-term

Annual bloodwork including metabolic panel, lipids, and HbA1c (if diabetic) should continue indefinitely

For example, a patient with type 2 diabetes on GLP-1 scheduled for hip replacement may continue the agent until 1 to 2 weeks pre-op if weight loss is modest, but stop earlier if gastroparesis or severe nausea is present