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However, GLP-1 receptor agonists may offer a more integrated solution

Forearm and hand injections are technically possible but less ideal because subcutaneous fat depth varies significantly in these areas and may be insufficient in some patients

For people with alcohol use disorder: If you have alcohol use disorder, you should not use this drug

More serious considerations include risk of pancreatitis, gallbladder problems, kidney injury (often related to dehydration from gastrointestinal symptoms), and rare cases of medullary thyroid cancer (these medications carry a black box warning for patients with personal or family history of MTC or MEN2 syndrome)