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To understand whether proglucagon might be processed to yield multiple proglucagon-derived peptides (PGDPs), including GLP-1 and GLP-2, Drucker transfected a proglucagon cDNA expression vector into fibroblasts, pituitary cells, and islet cells (15)

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Slim GM, Lansing M, Wizzard P, Nation PN, Wheeler SE, Brubaker PL, et al

The extensive role of GLP-1Rs and their agonists in other organs and tissues are shown in the overview in Fig