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Connective tissue disorders: Illnesses such as scleroderma can influence stomach muscle function
GLP-1 medications such as semaglutide and tirzepatide have transformed obesity and metabolic disease treatment

This will lubricate the trapped fiber block and allow it to pass safely without severe cramping

Roche for example paid $2.7bn to acquire privately held Carmot Therapeutics while AstraZeneca in-licensed an oral drug from Chinas Eccogene for $185m upfront (and $1.8bn of potential milestones)
