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As an adipocytokine, leptin governs food intake and energy homeostasis through leptin receptors (LepR) in the brain

At week 12, the absolute change in HbA1c from baseline was significantly greater in the tirzepatide treatment groups compared to the placebo group (placebo: +0.2% [0.21]

Other clinical trials evaluating the neuroprotective effects of GLP-1R agonism on AD are currently ongoing [839] GLP-1 analogs have also proven successful for the treatment of Parkinson's Disease (PD)

This is especially important for older people with type 2 diabetes, as they have an increased risk of osteoporosis and fractures (65)