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The FDA approved tirzepatide for chronic weight management for adults with obesity or with overweight and one weight-related comorbidity in November

Over 90% of participants on the highest dose achieved at least 5% weight loss, the threshold where metabolic improvements begin

Health Canada has approved 6 medications for long-term obesity management: liraglutide (Saxenda), naltrexonebupropion (Contrave), orlistat (Xenical), semaglutide (Wegovy), tirzepatide (Zepbound), and setmelanotide (Imcivree)

For researchers considering a taper schedule, the dosage calculator can help plan the exact reconstitution volumes needed at each reduced dose tier