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Description
There have been postmarketing reports of worsening renal function in patients taking sitagliptin with or without metformin, including acute renal failure, sometimes requiring dialysis
GLUT-4 levels in CON and HF were significantly lower than those in Ex and HF/Ex (P = 0.009, P = 0.003)
The reductions were modest, at around 10%, compared with a placebo, and Johannsen said it may take closer to 20% or 25% to translate into a real clinical benefit
In the postprandial state, insulin signaling activates LPL, a key mediator of the intake of triglyceride-derived fatty acids into cells
