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The investigational once-daily oral pill also reduced weight by an average of 16.0 lbs (7.9%) at the highest dose in a key secondary endpoint
The honest mechanistic summary is that most of retatrutides plausible benefit for PCOS insulin resistance would likely be indirect mediated by dramatic weight and hepatic-fat loss with a smaller, harder-to-isolate contribution from direct hepatic and islet effects
Kesselheim reports serving as an expert witness in litigation against Gilead relating to tenofovir-containing products
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