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Additionally, GLP-1RAs ameliorate DPN through various mechanisms, including the inhibition of inflammation, oxidative stress, and extracellular matrix remodeling, while simultaneously improving neural structure, function, and energy metabolism [11, 12, 30, 79,80,81,82,83,84,85,86]
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Injectable semaglutide, tested in the SUSTAIN trial series, showed similar or slightly higher weight reductionstypically 9% to 15%though these studies evaluated different populations and timeframes, making direct head-to-head comparison complex
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