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In this regard, four large randomized, double-blind, placebo controlled trials support the preventive use of topiramate alone for PTD-induced weight gain (1)

Yet by 2000, a strategy had emerged to prolong the effect of GLP-1 signaling: generate DPP-4 resistant peptides that bind and activate (i.e., agonize) GLP-1R

The mechanistic basis for this potential benefit is strong to help preserve muscle mass during such rapid and substantial weight loss, although this has not yet been studied

Chronic exposure to high glucose in intestinal organoids impairs the expression of transcription factors related to the differentiation of early and late endocrine progenitors and L-cell development including Ngn3 and Neurod1