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Description
Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64

This indicates that the desired and undesired effects of GLP-1 are indeed intertwined, said Yacawych

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Nat Commun 2017
