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doi: 10.1152/ajpendo.1996.271.3.E458

GLP-1 RAs also have a series of beneficial multifactorial effects beyond glycaemic control that include reduction of body weight and improvement of cardiovascular (CV) outcomes [14]

Patients consistently had improved glycemic levels and multiple drugs, such as tirzepatide alone or semaglutide in combination with cagrilinitide, were highly effective at promoting weight management

Moreover, mice with targeted inactivation of GLP-1R in autonomic neurons targeted by Phox2b, including the nodose ganglion, exhibit impaired glucose homeostasis, accelerated gastric emptying, and increased levels of GLP-1, glucagon, and insulin, supporting the importance of vagal afferent GLP-1Rs for metabolic homeostasis [520]