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The most well-known examples, apart from pioglitazone, are fenofibrate, pemafibrate, seladelpar, elafibranor and lanifibranor, which have been studied in various trials regarding their effect on liver inflammation and fibrosis, without particular success, with the exception of lanifibranor, a pan-PPAR agonist, which was shown in a phase 2b RCT (NATIVE-NCT03008070) to improve ballooning and inflammation, without worsening of fibrosis
Neuropharmacology 128:142151 Alvarez E, Martnez MD, Roncero I, Chowen JA, Garca-Cuartero B, Gispert JD, Sanz C, Vzquez P, Maldonado A, de Cceres J, Desco M, Pozo MA, Blzquez E (2005) The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem
Perez-Campos E, Mayoral L-C, Andrade G, Mayoral E-C, Huerta T, Canseco S, et al
