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Patients were also excluded if they met the ASA physical status classification of ASA 4 (patients with severe systemic disease threatening life) or ASA 5 (patients who were not expected to survive without surgery) (11)

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Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes, and Alzheimers disease

and (ii) the indiscriminate substitution of industrialized products already available and approved by ANVISA
