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Pharmacogenomic research continues to explore why some patients demonstrate robust responses while others show minimal weight change

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(2) Preparation of compound 4: activating the compound 3, and carrying out acylation coupling reaction on the activated compound and Arg34GLP-1 (9-37) terminal amino group in the compound 2 under the action of a condensation reagent and alkali to obtain a compound 4

Glucagon-like peptide-1 (GLP-1) is a hormone produced in the gut that is essential for regulating blood sugar levels