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Similar trends were observed for both population subgroups with T2D or overweight/obesity

Naltrexone sustained-release/bupropion sustained-release for the management of obesity: Review of the data to date

Gastroesophageal Reflux : Delayed gastric emptying, a therapeutic mechanism of tirzepatide, may paradoxically worsen gastroesophageal reflux disease (GERD) in susceptible individuals

This delay is what helps suppress appetite, but it also means your digestive system is working harder for longer periods