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It provides endothelial surface area for substrate exchange between the plasma compartment and the muscle interstitium

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In the U.S., for example, only 2% of the obese adult population were historically treated with anti-obesity drugs, due to a combination of lack of clarity about the role and value of pharmacotherapies (which were also less effective and sometimes with greater side effects than the recently launched treatments), limited insurance coverage and resulting out-of-pocket costs12
