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Furthermore, several novel therapeutic compounds (GIP receptor antagonists and agonists including multiple-targeting compounds) have also shown beneficial glucometabolic and body weight lowering effects in individuals with type 2 diabetes and obesity (40, 41)

He L, Wang J, Ping F, et al

Briefly, FFAs can reduce the tyrosine phosphorylation of insulin receptor substrate-1 by activating the serine/threonine kinase, thereby aggravating IR (151)

In one report, patients who lost more than five pounds after starting semaglutide showed reductions in TSH, suggesting that thyroid labs may shift during the early weight-loss phase