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Description
A 2025 bioRxiv preprint from Yale found that semaglutide alters the dopamine signals surrounding exercise in animal models, which complicates the simple narrative that the drug straightforwardly increases or decreases motivation to move

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The clinic file should explicitly note the off-label indication, the absence of T2D, and the patient's informed agreement to use a drug outside its registered label
Weekly dosing schedules maintain steady levels of semaglutide in the blood, keeping its concentration within the therapeutic range required to maintain blood sugar levels and keep the food noise away
