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The possible protective role of glucagon-like peptide 1 on endothelium during the meal and evidence for an endothelial resistance to glucagon-like peptide 1 in diabetes

Combining prolonged fasting, severe calorie restriction, intense exercise, and GLP-1 therapy at the same time can raise the risk of fatigue, dizziness, dehydration, poor nutrition, and lean muscle loss

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If headaches significantly impair quality of life or prevent continuation of treatment, the prescriber may consider dose adjustment, switching to an alternative medication, or discontinuation if necessary