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Frame it in terms of plateaued progress, need for additional appetite support, desire for the metabolic benefits the combination provides, or interest in accelerating fat loss while preserving muscle
The influence of metformin on cAMP production in MIN6 cells treated with 10 nM GLP-1 or GIP in the presence of 5.5 (a) or 16.7 mM glucose (b)
Weeks 1 to 4: 20 units (0.2 mL) once weekly Weeks 5 to 8: 40 units (0.4 mL) once weekly Weeks 9 to 12: 70 units (0.7 mL) once weekly Weeks 13 to 16: 90 units (0.9 mL) once weekly These are unit measurements based on insulin syringe markings
10.1038/ejcn.2014.256 63
