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The researchers pointed out that many patients in the observation group began taking nivolumab once it was approved or withdrew from the study, which may have skewed the results and made the overall survival data difficult to interpret

Brand-name manufacturers like Eli Lilly have faced shortages too, but their production scale and FDA prioritization typically resolve supply issues faster
Some people split into twice-daily dosing under provider guidance, taking half the dose in the morning and half in the evening
