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Discussion The use of GLP-1 RAs has risen rapidly in the United States because of their dual benefits of glycemic control and weight reduction, with 6% of adults reporting current use in 2024 and prevalence reaching 22% among those advised they were overweight or obese [8]

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"Wegovy Pill Approved in the US as First Oral GLP-1 for Weight Management." Novo Nordisk, 22 Dec

Furthermore, even removal of gene for CCK1 receptors, (CCK1 receptor knockout mouse) failed to increase the food intake, but resulted in the lack of the sensitivity of these animals to anorexigenic action of exogenous CCK (44)