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Description
The included studies on exendin-4 exposure were all performed in mouse models ( In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )
However, the degree of appetite suppression may vary from person to person, and some individuals may start feeling the effects sooner than others
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Given the demand for these agents, there have been several supply shortages leading to access issues and an increase in cost
