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If you have prediabetes or type 2 diabetes, your body tends to not make enough insulin, or your cells become less sensitive to it over time

A study found that people who slowly stepped down off semaglutide over about nine weeks, while following lifestyle coaching, maintained stable weight for 26 weeks after stopping
JAMA 331(1):3848 Ayodele T et al (2021) Early-onset Alzheimers disease: what is missing in research

The clinical trials and dosing guidelines reflect this distinction
