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They also slow gastric emptying, creating prolonged fullness that reduces appetite and induces weight loss
Combination therapy in the treatment of hypertension
GLP-1 RAs ameliorate hepatic steatosis through improved insulin sensitivity, direct suppression of hepatic de novo lipogenesis through AMPK activation and SREBP-1c inhibition, and enhanced fatty acid oxidation through PPAR upregulation
Discontinuing tirzepatide allows these underlying factors to reassert themselves
