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Introduction# Retatrutide and survodutide represent two next-generation approaches to obesity and metabolic disease treatment that go beyond single-target GLP-1 receptor agonism

If youre currently taking or have taken a monoamine oxidase inhibitor (MAOI), such as isocarboxazid, phenelzine, rasagiline, or tranylcypromine, in the last 14 days, tell your provider

The dosage of semaglutide depends on the indication: For type 2 diabetes: Start with 0.25 mg subcutaneously once weekly for the first 4 weeks, then increase to 0.5 mg once weekly

Injection site reactions manifest as redness, itching, or small nodules in some patientsproper rotation between injection sites and allowing the medication to reach room temperature before injection minimises these reactions