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Acknowledgements This work was supported by research grants from the National Key Research and Development Program of China (2016YFA0100501), the Chinese National 973 Program (2012CB517502), the National Natural Sciences Foundation of China (81400798, 81400767, 81401142, 81270858, and 81570692), and the Beijing Natural Sciences Foundation of China (7163233)

All authors reviewed and approved the final version of the manuscript for submission and publication

GLP-1 Side Effects at a Glance Nausea & vomiting Constipation Diarrhea Reflux & sulfur burps Loss of muscle and lean mass Skin, hair, and nail changes Fatigue, depression, and the blahs Dehydration Less Common but Serious Side Effects Pancreatitis and pancreatic cancer Gallstones & gallbladder disease Thyroid cancer Acute kidney injury Retinopathy, macular degeneration, and nonarteritic anterior ischemic optic neuropathy (NAION) Common GLP-1 Side Effects and How to Manage Them Most side effects show up early, often within the first few days of beginning GLP-1 treatment

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