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the improvement effects of the NPs and MNs treatment groups were not obvious, while the GLP-1RAs@NPs, GLP-1RAs@NPs-WYRGRL and MNs/GLP-1RAs@NPs-WYRGRL groups could effectively alleviate cartilage destruction and osteophyte formation, especially the MNs/GLP-1RAs@NPs-WYRGRL group (Fig

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