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When to suspect degradation even without visible signs Consider your vial potentially compromised if any of the following apply: It was left out of the fridge for more than 4 hours total It was exposed to temperatures above 30 degrees Celsius It was accidentally frozen, even briefly It has been open for more than 28 days It is past the printed Beyond-Use Date or expiration It was shipped without cold packs in warm weather Your results suddenly declined with no other explanation What happens if you use tirzepatide that has gone bad The consequences of using degraded tirzepatide fall into three categories, and the severity depends on the type and extent of degradation

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