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GLP-1 RAs have transformed the landscape of diabetes care by providing not only effective glycemic control but also substantial cardiovascular (CV) protection and significant weight loss [17,18]

GLP-1s, or GLP-1 receptor agonists, are medications that mimic the action of the naturally occurring hormone glucagon-like peptide-1 and occupy its receptors

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To overcome this limitation, scientists have developed GLP-1 receptor agonists (GLP-1 RAs), such as semaglutide, tilpotide, etc., which extend the half-life to the weekly formulation level through structural modification, achieving sustained regulation