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The engineered drug localized to lipid-rich plaque regions and CD11b/CD11c inflammatory cells, effectively suppressing inflammatory responses and enhancing cholesterol efflux ( By promoting cholesterol efflux and reducing foam-cell content within plaques, GLP-1RA therapy may decrease lipid core size and necrotic burden, thereby stabilizing the fibrous cap, lowering the risk of plaque rupture, and potentially reducing acute coronary events

Gipr fl/fl and Gipr Syn/ mice treated with mGIPR-Ab/P1 exhibited lower food intake (Fig

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The real effect of Mounjaro is seen beyond three months