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However, when only placebo-controlled studies were analysed, the impact of metformin on endogenous glucose production (EGP) was not significant unless concomitant drug-induced reductions in plasma insulin were used to adjust EGP [13]
Choi RH, Karasawa T, Meza CA, Maschek JA, Manuel AM, Nikolova LS, et al

Nutrition & diabetes , 3 (6), e78-e78

However, fewer and more minor side effects can only support an AOM and will likely be another contributing factor to success as patients potentially need to take these medicines for a number of years
