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This is expected, not pathological, and rarely requires additional intervention beyond giving the new medication time to reach steady state
Subsequent work done in low-carb/high-sat-fat diets appears to find no evidence of L-cell loss and some data even showed enhancement of GLP-1 responses long term
GLP-1 receptor agonists (like semaglutide, sold as Ozempic or Rybelsus) work by mimicking a gut hormone that helps regulate blood sugar, suppress appetite, and promote weight loss
In patients with volume depletion, correct this condition before initiating JARDIANCE
